Sugar in plaque is contributory cause of dental plaque diseases, meaning that sugars
with plaque bacteria can produce the dental cries and periodontal disease under proper
environmental condition. Sucrose is the one of the most causative material in all sugars
for the plaque diseases. Because of its biochemical properties, the sucrose may play a
major role in the development of smooth-surface caries than does in fissure caries and
periodontal disease. The metabolic by-products of sucrose includes extracellular
polysaccharide, which greatly increase the adherence of cariogenic mutans streptococci to
smooth enamel surfaces.
In this study, we tested the growth inhibition of some oral bacteria on the BHI
medium with glucose, fructose, sorbitol, and erythritol as sugar substitute in vitro. We
used sucrose as positive control and nonsugar as negative control. The tested 6 strains
were Streptococcus mutans KCTC 3065, Streptococcus sobrinus KCTC 3308,
Streptococcus rattus KCTC 3294, Streptococcus cricetus KCTC 3292, Actinobacillus
actinomycetemcomitans KCTC 2581, and Porphyromonas gingivalis ATCC 53978 strains.
The results obtained were as follows :
1. On the BHI medium with erythritol, the inhibitory effects of bacterial growth were
shown from 26.0% to 46.9% for all the tested 5 strains except S. sobrinus(p<0.01).
2. The effect of erythritol on bacterial growth inhibition with compared to sucrose
group as positive control were found to be from 32.7% to 61.4% growth inhibitory
ability for all the 6 tested strains(p<0.01).
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